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In addition to the SCD-HeFT study, there are three other primary prevention trials for sudden cardiac arrest. That is, these studies involve patients who are at risk for, but have not experienced sudden cardiac arrest. The trials are:
MADIT23
Objective:
Evaluate the effectiveness of ICD therapy (n = 99) versus conventional therapy (n = 101) in high risk MI patients
Inclusion Criteria:
- Q-wave MI > 3 weeks, and
- Asymptomatic, nonsustained ventricular tachycardia, and
- LVEF < 35%, and
- Inducible VT, but not suppressible on EPS, and
- NYHA Class I-III
ICD Results:
Reduced overall mortality by 54% (p = 0.009)
Reduced arrhythmic mortality by 75%
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